Attenuation of the Bacterial Load in Blood by Pretreatment with Granulocyte-Colony-Stimulating Factor Protects Rats from Fatal Outcome and Brain Damage during Streptococcus pneumoniae Meningitis

A model of pneumococcal meningitis in young adult rats receiving antibiotics once the infection was established was developed. The intent was to mimic clinical and histopathological features of pneumococcal meningitis in humans. The primary aim of the present study was to evaluate whether medical bo...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Brandt, Christian T., Lundgren, Jens D., Lund, Søren Peter, Frimodt-Møller, Niels, Christensen, Thomas, Benfield, Thomas, Espersen, Frank, Hougaard, David M., Østergaard, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC470620/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15271925/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.8.4647-4653.2004
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