Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

Ca(2+)-permeable type 2 two-pore channels (TPC2) are lysosomal proteins required for nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca(2+) release in many diverse cell types. Here, we investigate the importance of TPC2 proteins for the physiology and pathophysiology of the heart. NAADP...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Capel, Rebecca A., Bolton, Emma L., Lin, Wee K., Aston, Daniel, Wang, Yanwen, Liu, Wei, Wang, Xin, Burton, Rebecca-Ann B., Bloor-Young, Duncan, Shade, Kai-Ting, Ruas, Margarida, Parrington, John, Churchill, Grant C., Lei, Ming, Galione, Antony, Terrar, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705968/
https://ncbi.nlm.nih.gov/pubmed/26438825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684076
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