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Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders

Diabetes is strongly associated with cognitive decline, but the molecular reasons are unknown. We found that fasting and peripheral insulin promote phosphorylation and dephosphorylation, respectively, of specific residues on brain proteins including cytoskeletal regulators such as slit-robo GTPase-a...

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Pubblicato in:J Biol Chem
Autori principali: Li, Min, Quan, Chao, Toth, Rachel, Campbell, David G., MacKintosh, Carol, Wang, Hong Yu, Chen, Shuai
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705965/
https://ncbi.nlm.nih.gov/pubmed/26499801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668103
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