Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition

Eukaryotic structural maintenance of chromosome proteins (SMC) are major components of cohesin and condensins that regulate chromosome structure and dynamics during cell cycle. We here determine the crystal structure of human condensin SMC hinge heterodimer with ∼30 residues of coiled coils. The str...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Uchiyama, Susumu, Kawahara, Kazuki, Hosokawa, Yuki, Fukakusa, Shunsuke, Oki, Hiroya, Nakamura, Shota, Kojima, Yukiko, Noda, Masanori, Takino, Rie, Miyahara, Yuya, Maruno, Takahiro, Kobayashi, Yuji, Ohkubo, Tadayasu, Fukui, Kiichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705948/
https://ncbi.nlm.nih.gov/pubmed/26491021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670794
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