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FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy

FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction. We have previousl...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Olsvik, Hallvard L., Lamark, Trond, Takagi, Kenji, Larsen, Kenneth Bowitz, Evjen, Gry, Øvervatn, Aud, Mizushima, Tsunehiro, Johansen, Terje
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705940/
https://ncbi.nlm.nih.gov/pubmed/26468287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686915
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