Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B(12) Trafficking

Conversion of vitamin B(12) (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively. The intracellular proteins MMACHC and MMADHC...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Froese, D. Sean, Kopec, Jolanta, Fitzpatrick, Fiona, Schuller, Marion, McCorvie, Thomas J., Chalk, Rod, Plessl, Tanja, Fettelschoss, Victoria, Fowler, Brian, Baumgartner, Matthias R., Yue, Wyatt W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705923/
https://ncbi.nlm.nih.gov/pubmed/26483544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683268
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