Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL-l-METHIONINE ACTIVATION

Cystathionine β-synthase (CBS) is a key enzyme in sulfur metabolism, and its inherited deficiency causes homocystinuria. Mammalian CBS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain, which activates its catalytic domain. To investigate the underlying mechani...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: McCorvie, Thomas J., Kopec, Jolanta, Hyung, Suk-Joon, Fitzpatrick, Fiona, Feng, Xidong, Termine, Daniel, Strain-Damerell, Claire, Vollmar, Melanie, Fleming, James, Janz, Jay M., Bulawa, Christine, Yue, Wyatt W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276868/
https://ncbi.nlm.nih.gov/pubmed/25336647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610782
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