Disruption of the Aspergillus fumigatus Gene Encoding Nucleolar Protein CgrA Impairs Thermotolerant Growth and Reduces Virulence

Aspergillus fumigatus CgrA is the ortholog of a yeast nucleolar protein that functions in ribosome synthesis. To determine how CgrA contributes to the virulence of A. fumigatus, a ΔcgrA mutant was constructed by targeted gene disruption, and the mutant was reconstituted to wild type by homologous in...

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Bibliographische Detailangaben
Hauptverfasser: Bhabhra, Ruchi, Miley, Michael D., Mylonakis, Eleftherios, Boettner, Doug, Fortwendel, Jarrod, Panepinto, John C., Postow, Michael, Rhodes, Judith C., Askew, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC470587/
https://ncbi.nlm.nih.gov/pubmed/15271935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4731-4740.2004
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