Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice

Glucocorticoids (GC) are widely used as antiinflammatory/immunosuppressive drugs and antitumor agents in several types of lymphoma and leukemia. Therapeutic doses of GC induce growth-suppressive and cytotoxic effects on various leukocytes including B cells. Molecular mechanisms of GC action include...

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Vydáno v:Blood
Hlavní autoři: Bruscoli, Stefano, Biagioli, Michele, Sorcini, Daniele, Frammartino, Tiziana, Cimino, Monica, Sportoletti, Paolo, Mazzon, Emanuela, Bereshchenko, Oxana, Riccardi, Carlo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705834/
https://ncbi.nlm.nih.gov/pubmed/26276664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-631580
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