Probing the reactivity of singlet oxygen with purines

The reaction of singlet molecular oxygen with purine DNA bases is investigated by computational means. We support the formation of a transient endoperoxide for guanine and by classical molecular dynamics simulations we demonstrate that the formation of this adduct does not affect the B-helicity. We...

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Udgivet i:Nucleic Acids Res
Main Authors: Dumont, Elise, Grüber, Raymond, Bignon, Emmanuelle, Morell, Christophe, Moreau, Yohann, Monari, Antonio, Ravanat, Jean-Luc
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705671/
https://ncbi.nlm.nih.gov/pubmed/26656495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1364
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