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Automated physics-based design of synthetic riboswitches from diverse RNA aptamers
Riboswitches are shape-changing regulatory RNAs that bind chemicals and regulate gene expression, directly coupling sensing to cellular actuation. However, it remains unclear how their sequence controls the physics of riboswitch switching and activation, particularly when changing the ligand-binding...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4705656/ https://ncbi.nlm.nih.gov/pubmed/26621913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1289 |
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