Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination. High-titer functional antibodies are required against target antigens to achieve effective transmission-blocking act...

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Publicado no:Sci Rep
Main Authors: Li, Yuanyuan, Leneghan, Darren B., Miura, Kazutoyo, Nikolaeva, Daria, Brian, Iona J., Dicks, Matthew D. J., Fyfe, Alex J., Zakutansky, Sarah E., de Cassan, Simone, Long, Carole A., Draper, Simon J., Hill, Adrian V. S., Hill, Fergal, Biswas, Sumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705524/
https://ncbi.nlm.nih.gov/pubmed/26743316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18848
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