DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia

Close to half of de novo acute myeloid leukemia (AML) cases do not exhibit any cytogenetic aberrations. In this regard, distortion of the DNA methylation setting and the presence of mutations in epigenetic modifier genes can also be molecular drivers of the disease. In recent years, somatic missense...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ferreira, H J, Heyn, H, Vizoso, M, Moutinho, C, Vidal, E, Gomez, A, Martínez-Cardús, A, Simó-Riudalbas, L, Moran, S, Jost, E, Esteller, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705435/
https://ncbi.nlm.nih.gov/pubmed/26434589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.359
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