Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia

Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced AML, and PU.1 downregulation and/or dysfunction ha...

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Bibliographic Details
Published in:Leukemia
Main Authors: Sive, J I, Basilico, S, Hannah, R, Kinston, S J, Calero-Nieto, F J, Göttgens, B
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705427/
https://ncbi.nlm.nih.gov/pubmed/26126967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.172
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