Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation

The RabGAP AS160/TBC1D4 controls exocytosis of the insulin-sensitive glucose transporter Glut4 in adipocytes. Glut4 is internalized and recycled through a highly regulated secretory pathway in these cells. Glut4 also cycles through a slow constitutive endosomal pathway distinct from the fast transfe...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Brewer, Paul Duffield, Habtemichael, Estifanos N., Romenskaia, Irina, Mastick, Cynthia Corley, Coster, Adelle C. F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705397/
https://ncbi.nlm.nih.gov/pubmed/26527681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694919
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