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Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP) activity with trabectedin and PARP inhibitors, respectively,...
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| Publicado en: | J Breast Cancer |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Korean Breast Cancer Society
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4705084/ https://ncbi.nlm.nih.gov/pubmed/26770239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4048/jbc.2015.18.4.329 |
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