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Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Insulin-induced gene 1 (Insig-1) and Insig-2 are endoplasmic reticulum membrane–embedded sterol sensors that regulate the cellular accumulation of sterols. Despite their physiological importance, the structural information on Insigs remains limited. Here we report the high-resolution structures of M...
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| 發表在: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704858/ https://ncbi.nlm.nih.gov/pubmed/26160948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab1091 |
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