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GSK-3 Beta Does Not Stabilize Cryptochrome in the Circadian Clock of Drosophila

Cryptochrome (CRY) is the primary photoreceptor of Drosophila’s circadian clock. It resets the circadian clock by promoting light-induced degradation of the clock protein Timeless (TIM) in the proteasome. Under constant light, the clock stops because TIM is absent, and the flies become arrhythmic. I...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fischer, Robin, Helfrich-Förster, Charlotte, Peschel, Nicolai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704813/
https://ncbi.nlm.nih.gov/pubmed/26741981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146571
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