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Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome
Single‐channel recordings in CA3 pyramidal neurons revealed that large‐conductance calcium‐activated K(+) (BK) channel open probability was reduced by loss of fragile X mental retardation protein (FMRP) and that FMRP acts on BK channels by modulating the channel's gating kinetics. Fmr1/BKβ4 dou...
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| Publicado no: | J Physiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704506/ https://ncbi.nlm.nih.gov/pubmed/26427907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271031 |
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