Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria

Impaired organ perfusion in severe falciparum malaria arises from microvascular sequestration of parasitized cells and endothelial dysfunction. Endothelial dysfunction in malaria is secondary to impaired nitric oxide (NO) bioavailability, in part due to decreased plasma concentrations of l-arginine,...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Brussee, Janneke M., Yeo, Tsin W., Lampah, Daniel A., Anstey, Nicholas M., Duffull, Stephen B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704226/
https://ncbi.nlm.nih.gov/pubmed/26482311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01479-15
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