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Synthesis of Aza and Carbocyclic β-Carbolines for the Treatment of Alcohol Abuse. Regiospecific Solution to The Problem of 3,6-Disubstituted β-and Aza-β-carboline Specificity

A novel two step protocol was developed to gain regiospecific access to 3-substituted β-and aza-β-carbolines, 3-PBC (1), 3-ISOPBC (2), βCCt (3), 6-Aza-3-PBC (4) and 6-Aza-3-ISOPBC (5). These β-carbolines (1–3) are potential clinical agents to reduce alcohol self-administration, especially 3-ISOPBC·H...

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Bibliografische gegevens
Gepubliceerd in:Org Biomol Chem
Hoofdauteurs: Phani Babu Tiruveedhula, V. V. N., Methuku, Kashi Reddy, Deschamps, Jeffrey R., Cook, James M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704088/
https://ncbi.nlm.nih.gov/pubmed/26349488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01572c
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