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The propagation of perturbations in rewired bacterial gene networks

What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli. Here we report that concerted patterns of differential expression propagate from reconnected hub genes. The rewirings link promoter regions to dif...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Baumstark, Rebecca, Hänzelmann, Sonja, Tsuru, Saburo, Schaerli, Yolanda, Francesconi, Mirko, Mancuso, Francesco M., Castelo, Robert, Isalan, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703840/
https://ncbi.nlm.nih.gov/pubmed/26670742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10105
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