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The propagation of perturbations in rewired bacterial gene networks

What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli. Here we report that concerted patterns of differential expression propagate from reconnected hub genes. The rewirings link promoter regions to dif...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Baumstark, Rebecca, Hänzelmann, Sonja, Tsuru, Saburo, Schaerli, Yolanda, Francesconi, Mirko, Mancuso, Francesco M., Castelo, Robert, Isalan, Mark
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703840/
https://ncbi.nlm.nih.gov/pubmed/26670742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10105
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