Abasic pivot substitution harnesses target specificity of RNA interference

Gene silencing via RNA interference inadvertently represses hundreds of off-target transcripts. Because small interfering RNAs (siRNAs) can function as microRNAs, avoiding miRNA-like off-target repression is a major challenge. Functional miRNA–target interactions are known to pre-require transitiona...

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Pubblicato in:Nat Commun
Autori principali: Lee, Hye-Sook, Seok, Heeyoung, Lee, Dong Ha, Ham, Juyoung, Lee, Wooje, Youm, Emilia Moonkyung, Yoo, Jin Seon, Lee, Yong-Seung, Jang, Eun-Sook, Chi, Sung Wook
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703836/
https://ncbi.nlm.nih.gov/pubmed/26679372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10154
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