Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis

The transcription factor, runt-related transcription factor 2 (Runx2), plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages. We found by the drug repositioning strategy that a proton pump inhibitor, lansoprazole, enhances nuclear accumulation of...

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Библиографические подробности
Опубликовано в: :EBioMedicine
Главные авторы: Mishima, Kenichi, Kitoh, Hiroshi, Ohkawara, Bisei, Okuno, Tatsuya, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703748/
https://ncbi.nlm.nih.gov/pubmed/26844285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.11.024
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