A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

BACKGROUND: Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic cancer. Here, we investigated VEDT in patients with pancreatic ductal neoplasia in a window-of-opportunity preoperative clinical tri...

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Vydáno v:EBioMedicine
Hlavní autoři: Springett, Gregory M., Husain, Kazim, Neuger, Anthony, Centeno, Barbara, Chen, Dung-Tsa, Hutchinson, Tai Z., Lush, Richard M., Sebti, Saïd, Malafa, Mokenge P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703733/
https://ncbi.nlm.nih.gov/pubmed/26844278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.11.025
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