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HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK

BACKGROUND: HER-targeted tyrosine kinase inhibitors (TKIs) have demonstrated pro-apoptotic and antiproliferative effects in vitro and in vivo. The exact pathways through which TKIs exert their antineoplastic effects are, however, still not completely understood. METHODS: Using Milliplex assays, we h...

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Pubblicato in:PLoS One
Autori principali: Gschwantler-Kaulich, Daphne, Grunt, Thomas W., Muhr, Daniela, Wagner, Renate, Kölbl, Heinz, Singer, Christian F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703392/
https://ncbi.nlm.nih.gov/pubmed/26735495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146311
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