A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation

Translation initiation is a critical early step in the replication cycle of the positive-sense, single-stranded RNA genome of noroviruses, a major cause of gastroenteritis in humans. Norovirus RNA, which has neither a 5´ m(7)G cap nor an internal ribosome entry site (IRES), adopts an unusual mechani...

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Publicat a:PLoS Pathog
Autors principals: Leen, Eoin N., Sorgeloos, Frédéric, Correia, Samantha, Chaudhry, Yasmin, Cannac, Fabien, Pastore, Chiara, Xu, Yingqi, Graham, Stephen C., Matthews, Stephen J., Goodfellow, Ian G., Curry, Stephen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703368/
https://ncbi.nlm.nih.gov/pubmed/26734730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005379
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