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The Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-Pyrido[2,3-b]Indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice
2-Amino-9H-pyrido[2,3-b]indole (AαC), a carcinogen formed during the combustion of tobacco and cooking of meat, undergoes cytochrome P450 (P450) metabolism to form the DNA adduct N-(deoxyguanosin-8-yl)-2-amino-9H-pyrido[2,3-b]indole (dG-C8-AαC). We evaluated the roles of P450 expressed in the liver...
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| Publicado no: | Chem Res Toxicol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703101/ https://ncbi.nlm.nih.gov/pubmed/26583703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00405 |
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