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The Impact of NAT2 Acetylator Genotype on Mutagenesis and DNA Adducts from 2-Amino-9H-Pyrido[2,3-b]Indole
2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine (HAA) that is produced in high quantities in tobacco smoke, and also forms in charred meats. The bioactivation of AαC occurs by cytochrome P450-mediated (P450 1A2) N-oxidation of the exocyclic amine group, to form 2-h...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673018/ https://ncbi.nlm.nih.gov/pubmed/19243127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800473w |
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