5-hydroxymethylation of the EBV genome regulates the latent to lytic switch

Latent Epstein–Barr virus (EBV) infection and cellular hypermethylation are hallmarks of undifferentiated nasopharyngeal carcinoma (NPC). However, EBV infection of normal oral epithelial cells is confined to differentiated cells and is lytic. Here we demonstrate that the EBV genome can become 5-hydr...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wille, Coral K., Nawandar, Dhananjay M., Henning, Amanda N., Ma, Shidong, Oetting, Kayla M., Lee, Dennis, Lambert, Paul, Johannsen, Eric C., Kenney, Shannon C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703011/
https://ncbi.nlm.nih.gov/pubmed/26663912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513432112
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