Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation

The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-κB) activation, which is required for tumor cell survival. BCR-induced NF-κB activation requires caspase recruitment...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Knies, Nathalie, Alankus, Begüm, Weilemann, Andre, Tzankov, Alexandar, Brunner, Kristina, Ruff, Tanja, Kremer, Marcus, Keller, Ulrich B., Lenz, Georg, Ruland, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702996/
https://ncbi.nlm.nih.gov/pubmed/26668357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507459112
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