CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages

Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which is believed to predispose obese individuals to insulin resistance. CD11b (integrin α(M)) is highly expressed on monocytes and macrophages and is critical for their migration and function. W...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zheng, Chunxing, Yang, Qian, Xu, Chunliang, Shou, Peishun, Cao, Jianchang, Jiang, Menghui, Chen, Qing, Cao, Gang, Han, Yanyan, Li, Fengying, Cao, Wei, Zhang, Liying, Zhang, Li, Shi, Yufang, Wang, Ying
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702980/
https://ncbi.nlm.nih.gov/pubmed/26669445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500396113
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