CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages

Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which is believed to predispose obese individuals to insulin resistance. CD11b (integrin α(M)) is highly expressed on monocytes and macrophages and is critical for their migration and function. W...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zheng, Chunxing, Yang, Qian, Xu, Chunliang, Shou, Peishun, Cao, Jianchang, Jiang, Menghui, Chen, Qing, Cao, Gang, Han, Yanyan, Li, Fengying, Cao, Wei, Zhang, Liying, Zhang, Li, Shi, Yufang, Wang, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702980/
https://ncbi.nlm.nih.gov/pubmed/26669445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500396113
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