Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4(+) T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues

Lymphoid tissues (LTs) are the principal sites where human immunodeficiency virus type 1 (HIV-1) replicates and virus-host interactions take place, resulting in immunopathology in the form of inflammation, immune activation, and CD4(+) T cell death. The HIV-1 pathogenesis in LTs has been extensively...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Lu, Wuxun, Demers, Andrew J., Ma, Fangrui, Kang, Guobin, Yuan, Zhe, Wan, Yanmin, Li, Yue, Xu, Jianqing, Lewis, Mark, Li, Qingsheng
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702687/
https://ncbi.nlm.nih.gov/pubmed/26559826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02297-15
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