Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

Seasonal influenza is a vaccine-preventable disease that remains a major health problem worldwide, especially in immunocompromised populations. The impact of influenza disease is even greater when strains drift, and influenza pandemics can result when animal-derived influenza virus strains combine w...

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Bibliographic Details
Published in:J Virol
Main Authors: Brazzoli, Michela, Magini, Diletta, Bonci, Alessandra, Buccato, Scilla, Giovani, Cinzia, Kratzer, Roland, Zurli, Vanessa, Mangiavacchi, Simona, Casini, Daniele, Brito, Luis M., De Gregorio, Ennio, Mason, Peter W., Ulmer, Jeffrey B., Geall, Andrew J., Bertholet, Sylvie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702536/
https://ncbi.nlm.nih.gov/pubmed/26468547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01786-15
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