Low stromal Foxp3(+) regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer

BACKGROUND: Foxp3(+) regulatory T cells (Tregs) play a vital role in preventing autoimmunity, but also suppress antitumour immune responses. Tumour infiltration by Tregs has strong prognostic significance in colorectal cancer, and accumulating evidence suggests that chemotherapy and radiotherapy eff...

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Pubblicato in:Br J Cancer
Autori principali: McCoy, M J, Hemmings, C, Miller, T J, Austin, S J, Bulsara, M K, Zeps, N, Nowak, A K, Lake, R A, Platell, C F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702002/
https://ncbi.nlm.nih.gov/pubmed/26645238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.427
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