Low stromal Foxp3(+) regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer

BACKGROUND: Foxp3(+) regulatory T cells (Tregs) play a vital role in preventing autoimmunity, but also suppress antitumour immune responses. Tumour infiltration by Tregs has strong prognostic significance in colorectal cancer, and accumulating evidence suggests that chemotherapy and radiotherapy eff...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: McCoy, M J, Hemmings, C, Miller, T J, Austin, S J, Bulsara, M K, Zeps, N, Nowak, A K, Lake, R A, Platell, C F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702002/
https://ncbi.nlm.nih.gov/pubmed/26645238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.427
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