Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1(G93A) Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration and loss of motor neurons in the spinal cord, brainstem and motor cortex. Up to 10% of ALS cases are inherited (familial, fALS) and associated with mutations, frequently in the superoxide dis...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Gajowiak, Anna, Styś, Agnieszka, Starzyński, Rafał R., Bednarz, Aleksandra, Lenartowicz, Małgorzata, Staroń, Robert, Lipiński, Paweł
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701970/
https://ncbi.nlm.nih.gov/pubmed/26778957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00082
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