A drastic superoxide-dependent oxidative stress is prerequisite for the down-regulation of IRP1: Insights from studies on SOD1-deficient mice and macrophages treated with paraquat

Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism. Superoxide radical (O(2)(.-)) converts IRP1 from a...

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Udgivet i:PLoS One
Main Authors: Milczarek, Anna, Starzyński, Rafał R., Styś, Agnieszka, Jończy, Aneta, Staroń, Robert, Grzelak, Agnieszka, Lipiński, Paweł
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438123/
https://ncbi.nlm.nih.gov/pubmed/28542246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176800
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