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Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

Cathepsin D (EC 3.4.23.5) is a lysosomal protease suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression. Determination of the crystal structures of cathepsin D and a complex with pepstatin at 2.5 A resolution provides insigh...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Baldwin, E T, Bhat, T N, Gulnik, S, Hosur, M V, Sowder, R C, Cachau, R E, Collins, J, Silva, A M, Erickson, J W
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47019/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393577/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6796
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