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Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X

Egress of Plasmodium from host erythrocytes is mediated by effector proteins. Aspartic protease plasmepsin X (PM X) regulates the activity for many of these effectors, is essential for replication and is a promising drug target. Here, Mukherjee et al. map the self-cleavage sites of PM X, show that t...

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Autors principals: Sumit Mukherjee, Suong Nguyen, Eashan Sharma, Daniel E. Goldberg
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-08-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-022-32271-7
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