Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate

Dichloroacetate (DCA) and pyruvate activate pyruvate dehydrogenase (PDH), a key enzyme that modulates glucose oxidation and mitochondrial NADH production. Both compounds improve recovery after ischemia in isolated hearts. However, the action of DCA and pyruvate in normoxic myocardium is incompletely...

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Bibliographic Details
Published in:Pflugers Arch
Main Authors: Jaimes, Rafael, Kuzmiak-Glancy, Sarah, Brooks, Daina M., Swift, Luther M., Posnack, Nikki G., Kay, Matthew W.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701640/
https://ncbi.nlm.nih.gov/pubmed/26142699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-015-1717-1
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