Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate

Dichloroacetate (DCA) and pyruvate activate pyruvate dehydrogenase (PDH), a key enzyme that modulates glucose oxidation and mitochondrial NADH production. Both compounds improve recovery after ischemia in isolated hearts. However, the action of DCA and pyruvate in normoxic myocardium is incompletely...

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Detaylı Bibliyografya
Yayımlandı:Pflugers Arch
Asıl Yazarlar: Jaimes, Rafael, Kuzmiak-Glancy, Sarah, Brooks, Daina M., Swift, Luther M., Posnack, Nikki G., Kay, Matthew W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701640/
https://ncbi.nlm.nih.gov/pubmed/26142699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-015-1717-1
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