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Endothelial LRP1 transports amyloid-β(1–42) across the blood-brain barrier

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer’s disease (AD) pathology. However, due to conflict...

詳細記述

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書誌詳細
出版年:J Clin Invest
主要な著者: Storck, Steffen E., Meister, Sabrina, Nahrath, Julius, Meißner, Julius N., Schubert, Nils, Di Spiezio, Alessandro, Baches, Sandra, Vandenbroucke, Roosmarijn E., Bouter, Yvonne, Prikulis, Ingrid, Korth, Carsten, Weggen, Sascha, Heimann, Axel, Schwaninger, Markus, Bayer, Thomas A., Pietrzik, Claus U.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701557/
https://ncbi.nlm.nih.gov/pubmed/26619118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81108
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