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Endothelial LRP1 transports amyloid-β(1–42) across the blood-brain barrier
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer’s disease (AD) pathology. However, due to conflict...
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出版年: | J Clin Invest |
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主要な著者: | , , , , , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
American Society for Clinical Investigation
2015
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4701557/ https://ncbi.nlm.nih.gov/pubmed/26619118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81108 |
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