Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

Ecto-5′-nucleotidase (CD73) is central to the generation of extracellular adenosine. Previous studies have highlighted a detrimental role for extracellular adenosine in cancer, as it dampens T cell–mediated immune responses. Here, we determined that, in contrast to other cancers, CD73 is markedly do...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Bowser, Jessica L., Blackburn, Michael R., Shipley, Gregory L., Molina, Jose G., Dunner, Kenneth, Broaddus, Russell R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701552/
https://ncbi.nlm.nih.gov/pubmed/26642367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79380
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