Immune activation caused by vascular oxidation promotes fibrosis and hypertension

Vascular oxidative injury accompanies many common conditions associated with hypertension. In the present study, we employed mouse models with excessive vascular production of ROS (tg(sm/p22phox) mice, which overexpress the NADPH oxidase subunit p22(phox) in smooth muscle, and mice with vascular-spe...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wu, Jing, Saleh, Mohamed A., Kirabo, Annet, Itani, Hana A., Montaniel, Kim Ramil C., Xiao, Liang, Chen, Wei, Mernaugh, Raymond L., Cai, Hua, Bernstein, Kenneth E., Goronzy, Jörg J., Weyand, Cornelia M., Curci, John A., Barbaro, Natalia R., Moreno, Heitor, Davies, Sean S., Roberts, L. Jackson, Madhur, Meena S., Harrison, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701546/
https://ncbi.nlm.nih.gov/pubmed/26595812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80761
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