p21(CDKN1A) Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates

The cell cycle inhibitor p21(CDKN1A) was previously found to interact directly with DNA nick-sensor poly(ADP-ribose) polymerase-1 (PARP-1) and to promote base excision repair (BER). However, the molecular mechanism responsible for this BER-related association of p21 with PARP-1 remains to be clarifi...

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Publicat a:PLoS One
Autors principals: Dutto, Ilaria, Sukhanova, Maria, Tillhon, Micol, Cazzalini, Ornella, Stivala, Lucia A., Scovassi, A. Ivana, Lavrik, Olga, Prosperi, Ennio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701469/
https://ncbi.nlm.nih.gov/pubmed/26730949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146031
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