A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9

Poor outcome in response to hepatitis C virus, including higher viral load, hepatocellular carcinoma and cirrhosis, is more associated with men and postmenopausal women than with premenopausal women and women receiving hormone replacement therapy, suggesting that β-estradiol plays an innate role in...

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Udgivet i:PLoS One
Main Authors: Ulitzky, Laura, Lafer, Manuel M., KuKuruga, Mark A., Silberstein, Erica, Cehan, Nicoleta, Taylor, Deborah R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701175/
https://ncbi.nlm.nih.gov/pubmed/26731262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145212
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