Mutated Leguminous Lectin Containing a Heparin-Binding like Motif in a Carbohydrate-Binding Loop Specifically Binds to Heparin

We previously introduced random mutations in the sugar-binding loops of a leguminous lectin and screened the resulting mutated lectins for novel specificities using cell surface display. Screening of a mutated peanut agglutinin (PNA), revealed a mutated PNA with a distinct preference for heparin. Gl...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Abo, Hirohito, Soga, Keisuke, Tanaka, Atsuhiro, Tateno, Hiroaki, Hirabayashi, Jun, Yamamoto, Kazuo
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701002/
https://ncbi.nlm.nih.gov/pubmed/26714191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145834
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