Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells

T regulatory cells that express the transcription factor Foxp3 (Foxp3+ Treg) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses. This ind...

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Veröffentlicht in:Science
Hauptverfasser: Sefik, Esen, Geva-Zatorsky, Naama, Oh, Sungwhan, Konnikova, Liza, Zemmour, David, McGuire, Abigail Manson, Burzyn, Dalia, Ortiz-Lopez, Adriana, Lobera, Mercedes, Yang, Jianfei, Ghosh, Shomir, Earl, Ashlee, Snapper, Scott B., Jupp, Ray, Kasper, Dennis, Mathis, Diane, Benoist, Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700932/
https://ncbi.nlm.nih.gov/pubmed/26272906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa9420
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